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Non-Kolbe electrolysis of N-protected-α-amino acids: a standardized method for the synthesis of N-protected (1-methoxyalkyl)amines.

ABSTRACT: Here, we report a standardized method for the synthesis of N-protected (1-methoxyalkyl)amines by the electrochemical decarboxylative α-methoxylation of α-amino acid derivatives using the commercially available, easy-to-use, compact ElectraSyn 2.0 setup. The use of equipment with a standardized power source, electrodes, and other accessories allows this experimental procedure to be easily transferred to any laboratory in the world. A simple workup and chromatography-free purification produced the products in excellent yields above 90%.

SUBMITTER: Walecka-Kurczyk A 

PROVIDER: S-EPMC8979322 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Non-Kolbe electrolysis of <i>N</i>-protected-α-amino acids: a standardized method for the synthesis of <i>N</i>-protected (1-methoxyalkyl)amines.

Walęcka-Kurczyk A A   Adamek J J   Walczak K K   Michalak M M   Październiok-Holewa A A  

RSC advances 20220112 4

Here, we report a standardized method for the synthesis of <i>N</i>-protected (1-methoxyalkyl)amines by the electrochemical decarboxylative α-methoxylation of α-amino acid derivatives using the commercially available, easy-to-use, compact ElectraSyn 2.0 setup. The use of equipment with a standardized power source, electrodes, and other accessories allows this experimental procedure to be easily transferred to any laboratory in the world. A simple workup and chromatography-free purification produ  ...[more]

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