CO₂-Assisted asymmetric hydrogenation of prochiral allylamines.

ABSTRACT: A new methodology for the asymmetric hydrogenation of allylamines takes advantage of a reversible reaction between amines and carbon dioxide (CO₂) to suppress unwanted side reactions. The effects of various parameters (pressure, time, solvent, and base additives) on the enantioselectivity and conversion of the reaction were studied. The homogeneously-catalyzed asymmetric hydrogenation of 2-arylprop-2-en-1-amine resulted in complete conversion and up to 82% enantiomeric excess (ee). Added base, if chosen carefully, improves the enantioselectivity and chemoselectivity of the overall reaction.

SUBMITTER: de Winter TM 

PROVIDER: S-EPMC8981594 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature