GJLS2: an R package for generalized joint location and scale analysis in X-inclusive genome-wide association studies.

ABSTRACT: A joint analysis of location and scale can be a powerful tool in genome-wide association studies to uncover previously overlooked markers that influence a quantitative trait through both mean and variance, as well as to prioritize candidates for gene-environment interactions. This approach has recently been generalized to handle related samples, dosage data, and the analytically challenging X-chromosome. We disseminate the latest advances in methodology through a user-friendly R software package with added functionalities to support genome-wide analysis on individual-level or summary-level data. The implemented R package can be called from PLINK or directly in a scripting environment, to enable a streamlined genome-wide analysis for biobank-scale data. Application results on individual-lev

SUBMITTER: Deng WQ 

PROVIDER: S-EPMC8982384 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature