Ontology highlight
ABSTRACT:
SUBMITTER: Chan CK
PROVIDER: S-EPMC8982443 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Chan Chieh-Kai CK Chung Yi-Hsiu YH Wang Cheng-Chung CC
RSC advances 20220315 13
An efficient protocol for the preparation of pyridine skeletons has been successfully developed involving the TMSOTf/HMDS (trifluoromethanesulfonic acid/hexamethyldisilane) system for the intermolecular cyclization of chalcones under MW (microwave) irradiation conditions. This method provides a facile approach to synthesize 2,4,6-triaryl or 3-benzyl-2,4,6-triarylpyridines in good to excellent yields. Interestingly, the 2,6-diazabicyclo[2.2.2]oct-2-ene core was obtained by changing the acid addit ...[more]