Vaccination Against SARS-CoV-2 Is Associated With a Lower Viral Load and Likelihood of Systemic Symptoms.

ABSTRACT:

Background

Data conflict on whether vaccination decreases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load. The objective of this analysis was to compare baseline viral load and symptoms between vaccinated and unvaccinated adults enrolled in a randomized trial of outpatient coronavirus disease 2019 (COVID-19) treatment.

Methods

Baseline data from the first 433 sequential participants enrolling into the COVID-OUT trial were analyzed. Adults aged 30-85 with a body mass index (BMI) ≥25 kg/m² were eligible within 3 days of a positive SARS-CoV-2 test and <7 days of symptoms. Log₁₀ polymerase chain reaction viral loads were normalized to human RNase P by vaccination status, by time from vaccination, and by symptoms.

Results

Two h

SUBMITTER: Bramante CT 

PROVIDER: S-EPMC8982774 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature