Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families.

ABSTRACT:

Background

Migraine is diagnosed using the extensively field-tested International Classification of Headache Disorders (ICHD-3) consensus criteria derived by the International Headache Society. To evaluate the criteria in respect to a measurable biomarker, we studied the relationship between the main ICHD-3 criteria and the polygenic risk score, a measure of common variant burden in migraine.

Methods

We used linear mixed models to study the correlation of ICHD-3 diagnostic criteria, underlying symptoms, and main diagnoses with the polygenic risk score of migraine in a cohort of 8602 individuals from the Finnish Migraine Genome Project.

Results

Main diagnostic categories and all underlying diagnostic criteria formed a consistent continuum along the increasing polygenic

SUBMITTER: Happola P 

PROVIDER: S-EPMC8988286 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature