Mesial temporal tau in amyloid-β-negative cognitively normal older persons.

ABSTRACT:

Background

Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ-) occurs with aging. The tau PET tracer ¹⁸F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ- cognitively unimpaired (CU) individuals.

Methods

One hundred and ninety-nine Aβ- participants (Centiloid < 25) who were CU underwent ¹⁸F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuou

SUBMITTER: Krishnadas N 

PROVIDER: S-EPMC8991917 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature