Epigenetic regulation and targeting of ECM for cancer therapy.

ABSTRACT: The tumor microenvironment (TME) composed of different types of cells embedded in extracellular matrix (ECM) has crucial effects on cancer growth and metastasis. ECM is made of a variety of proteins that provide structural support to the cells and regulate biological functions by modulating the cross talk among cells, thus effecting tumor growth and progression. In this mini-review, the author discusses epigenetic modifications that regulate the expression of fibrous ECM proteins and glycoproteins and the prospects of targeting them for cancer therapy.

SUBMITTER: Gupta R 

PROVIDER: S-EPMC8993518 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature