Dataset Information

Low levels of serum IL-39 are associated with autoimmune thyroid disease.

ABSTRACT:

Background

Interleukin (IL)-39 is a novel member of IL-12 cytokine family, but its role in autoimmune thyroid diseases (AITD) is unclear. The aim of the present study was to determine serum levels of IL-39 in Hashimoto's thyroiditis (HT) and Graves' disease (GD) patients.

Methods

A total of 48 patients with HT, 50 patients with GD, and 45 healthy controls (HCs) were recruited for this study. Levels of serum IL-39 were determined by ELISA.

Results

Compared with HC group, levels of serum IL-39 in patients with HT (p < 0.05) and GD (p < 0.01) were drastically reduced. Among patients with HT, serum IL-39 levels had a positive correlation with white blood cell count (WBC) count and free triiodothyronine level. Among patients with GD, the levels of IL-39 in serum were positively correlated with WBC count and C-reactive protein levels.

Conclusions

IL-39 may be a new potential predictor for patients with HT and GD.

SUBMITTER: Weng L

PROVIDER: S-EPMC8993603 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

Low levels of serum IL-39 are associated with autoimmune thyroid disease.

Weng Linjie L Huang Guoqing G Gong Luping L Xu Jialu J Mao Yushan Y Li Yan Y Li Mingcai M

Journal of clinical laboratory analysis 20220219 4

<h4>Background</h4>Interleukin (IL)-39 is a novel member of IL-12 cytokine family, but its role in autoimmune thyroid diseases (AITD) is unclear. The aim of the present study was to determine serum levels of IL-39 in Hashimoto's thyroiditis (HT) and Graves' disease (GD) patients.<h4>Methods</h4>A total of 48 patients with HT, 50 patients with GD, and 45 healthy controls (HCs) were recruited for this study. Levels of serum IL-39 were determined by ELISA.<h4>Results</h4>Compared with HC group, lev ...[more]

PMID: 35182078

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Dataset Information

Low levels of serum IL-39 are associated with autoimmune thyroid disease.

Background

Methods

Results

Conclusions

Publications

Low levels of serum IL-39 are associated with autoimmune thyroid disease.

Similar Datasets

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