From basic to advanced computerised intravenous to oral switch for paracetamol and antibiotics: an interrupted time series analysis.

ABSTRACT:

Objectives

Early switch from intravenous to oral therapy of bioequivalent drugs has major advantages but remains challenging. At our hospital, a basic clinical rule was designed to automatically alert the physician to review potential intravenous to oral switch (IVOS). A rather low acceptance rate was observed. In this study, we aimed to develop, validate and investigate the effect of more advanced clinical rules for IVOS, as part of a centralised pharmacist-led medication review service.

Design and setting

A quasi-experimental study was performed in a large teaching hospital in Belgium using an interrupted time series design.

Intervention

A definite set of 13 criteria for IVOS, focusing on the ability of oral absorption and type of infection, was obtained by literatu

SUBMITTER: Quintens C 

PROVIDER: S-EPMC8995958 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature