Peripheral lymphocyte populations in ovarian cancer patients and correlations with clinicopathological features.

ABSTRACT:

Background

To investigate the alterations of peripheral lymphocyte subpopulations in ovarian cancer patients compared to benign or borderline counterparts. The possible clinicopathological implications were also evaluated.

Methods

We enrolled 112 treatment-naive ovarian cancer patients, 14 borderline tumor patients and 44 benign tumor patients between 09/2016 and 01/2019. Flow cytometry was used to measure the peripheral lymphocyte subsets consisting of T cells (CD3⁺, CD3⁺CD4⁺, CD3⁺CD8⁺ and CD8⁺CD28⁺), regulatory T cells (Tregs, CD4⁺CD25⁺CD127^-), natural killer cells (NK cells, CD3^-CD56⁺) and B cells (CD19⁺).

Results

Most ovari

SUBMITTER: Ye S 

PROVIDER: S-EPMC8996636 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature