Risk Stratification by Cross-Classification of Central and Brachial Systolic Blood Pressure.

ABSTRACT:

Background

Whether cardiovascular risk is more tightly associated with central (cSBP) than brachial (bSBP) systolic pressure remains debated, because of their close correlation and uncertain thresholds to differentiate cSBP into normotension versus hypertension.

Methods

In a person-level meta-analysis of the International Database of Central Arterial Properties for Risk Stratification (n=5576; 54.1% women; mean age 54.2 years), outcome-driven thresholds for cSBP were determined and whether the cross-classification of cSBP and bSBP improved risk stratification was explored. cSBP was tonometrically estimated from the radial pulse wave using SphygmoCor software.

Results

Over 4.1 years (median), 255 composite cardiovascular end points occurred. In multivariable bootstrapp

SUBMITTER: Cheng YB 

PROVIDER: S-EPMC8997688 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature