Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3β-Mediated Autophagy.

ABSTRACT: More and more attention has been paid to the use of traditional phytochemicals. Here, we first verified the therapeutic potential of a natural bioactive compound called Hinokitiol in myocardial ischemia reperfusion injury. Hinokitiol exerts cardioprotective effect through inhibition of GSK-3β and subsequent elimination of excessive autophagy, tuning autophagic activity in moderate extent for remedial profit in acute myocardial infarction and myocardial ischemia reperfusion injury. Overall, our study establishes Hinokitiol as a novel available interventional treatment for myocardial ischemia reperfusion injury.

SUBMITTER: Xiao H 

PROVIDER: S-EPMC9001072 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature