Prognostic value of microvascular resistance and its association to fractional flow reserve: a DEFINE-FLOW substudy.

ABSTRACT:

Objective

This study aimed to evaluate the prognostic value of hyperemic microvascular resistance (HMR) and its relationship with hyperemic stenosis resistance (HSR) index and fractional flow reserve (FFR) in stable coronary artery disease.

Methods

This is a substudy of the DEFINE-FLOW cohort (NCT02328820), which evaluated the prognosis of lesions (n=456) after combined FFR and coronary flow reserve (CFR) assessment in a prospective, non-blinded, non-randomised, multicentre study in 12 centres in Europe and Japan. Participants (n=430) were evaluated by wire-based measurement of coronary pressure, flow and vascular resistance (ComboWire XT, Phillips Volcano, San Diego, California, USA).

Results

Mean FFR and CFR were 0.82±0.10 and 2.2±0.6, respectively. When divided acc

SUBMITTER: Eftekhari A 

PROVIDER: S-EPMC9003618 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature