Cyclin B2 overexpression promotes tumour growth by regulating jagged 1 in hepatocellular carcinoma.

ABSTRACT:

Background

Our previous study showed that Cyclin B2 (CCNB2) is closely related to the occurrence and progression of hepatocellular carcinoma (HCC).

Aim of the study

This study aimed to clarify the effect of CCNB2 gene silencing on tumorigenesis in nude mice and to detect the potential mechanism.

Methods

The effect of CCNB2 on HCC was tested in vivo. The downstream target genes of CCNB2 were predicted by proteomics and confirmed by western blot assay. The regulatory functions of CCNB2 in the proliferation and migration of HCC cells were determined through functional recovery experiments. The expression of the downstream target genes of CCNB2 was detected by immunohistochemistry.

Results

Knockdown of CCNB2 decrease

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC9004552 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature