Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis.

ABSTRACT: Tumors are composed of the tumor cells and the surrounding microenvironment. Both are closely interwoven and interact by a complex and multifaceted cross-talk which plays an integral part in tumor initiation, growth, and progression. Dro1/Ccdc80 has been shown to be a potent suppressor of colorectal cancer and ubiquitous inactivation of Dro1/Ccdc80 strongly promoted colorectal carcinogenesis in Apc^Min/+ mice and in a chemically-induced colorectal cancer model. The aim of the present study was to investigate whether Dro1/Ccdc80's tumor suppressive function is tumor-cell-autonomous. Expression of Dro1/Ccdc80 in cancer cells had no effect on both colon tumor development in Apc^Min/+ mice and formation of xenograft tumors. In contr

SUBMITTER: Christian JI 

PROVIDER: S-EPMC9004603 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature