Model-based meta-analysis of salbutamol pharmacokinetics and practical implications for doping control.

ABSTRACT: Salbutamol was included in the prohibited list of the World Anti-Doping Agency (WADA) in 2004. Although systemic intake is banned, inhalation for asthma is permitted but with dosage restrictions. The WADA established a urinary concentration threshold to distinguish accordingly prohibited systemic self-administration from therapeutic prescription by inhalation. This study aimed at evaluating the ability of the WADA threshold to differentiate salbutamol therapeutic use from violation of antidoping rules. Concentration-time profile of salbutamol in plasma and its excretion in urine was characterized through a model-based meta-analysis of individual and aggregate data collected after administration of a large range of doses following different modes of administration and under a variety of con

SUBMITTER: Courlet P 

PROVIDER: S-EPMC9007606 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature