The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue.
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ABSTRACT:
SUBMITTER: Sehl ME
PROVIDER: S-EPMC9007943 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue.
Sehl Mary E ME Henry Jill E JE Storniolo Anna Maria AM Horvath Steve S Ganz Patricia A PA
NPJ breast cancer 20220413 1
Estrogen promotes breast tissue proliferation and telomerase activation. We investigated the effects of reproductive history on cell cycling and telomere length using a DNA methylation-based estimate of telomere length (DNAmTL) in breast and blood from healthy women donors. We demonstrate that DNAmTL is shorter in breast than in blood, and that nulliparous women have longer age-adjusted DNAmTL in both breast and blood, potentially explaining their higher risk of breast cancer. ...[more]
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