High-cytocompatible semi-IPN bio-ink with wide molecular weight distribution for extrusion 3D bioprinting.

ABSTRACT: The development of 3D printing has recently attracted significant attention on constructing complex three-dimensional physiological microenvironments. However, it is very challenging to provide a bio-ink with cell-harmless and high mold accuracy during extrusion in 3D printing. To overcome this issue, a technique improving the shear-thinning performance of semi-IPN bio-ink, which is universally applicable to all alginate/gelatin-based materials, was developed. Semi-IPN bio-ink prepared by cyclic heating-cooling treatment in this study can reduce the cell damage without sacrificing the accuracy of the scaffolds for its excellent shear-thinning performance. A more than 15% increase in post-printing Cell viability verified the feasibility of the strategy. Moreover, the bio-ink with low molecu

SUBMITTER: Li M 

PROVIDER: S-EPMC9012805 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature