Independent External Validation and Comparison of Death and Kidney Replacement Therapy Prediction Models in Advanced CKD.

ABSTRACT:

Rationale & objective

The Kidney Failure Risk Equation (KFRE) is widely used to predict the risk of kidney replacement therapy (KRT) initiation in chronic kidney disease (CKD) stages G3-G5. The new Grams calculator developed for advanced CKD (stage G4+) predicts KRT initiation, cardiovascular events, and death by uniquely incorporating the competing risk of death. We aimed to validate this tool in a stage G4+ cohort for death and KRT.

Study design

Retrospective cohort study.

Setting & participants

442 patients with CKD stage G4+ (mean ± SD age, 73 ± 12 years; mean ± SD estimated glomerular filtration rate, 20 ± 6.2 mL/min/1.73 m²) who visited the multidisciplinary CKD clinic at Kingston Health Sciences Center in Ontario, Canada.

Outcomes & analytical app

SUBMITTER: Thanabalasingam SJ 

PROVIDER: S-EPMC9014437 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature