Comparative genome analysis reveals a complex population structure of Legionella pneumophila subspecies.

ABSTRACT: The majority of Legionnaires' disease (LD) cases are caused by Legionella pneumophila, a genetically heterogeneous species composed of at least 17 serogroups. Previously, it was demonstrated that L. pneumophila consists of three subspecies: pneumophila, fraseri and pascullei. During an LD outbreak investigation in 2012, we detected that representatives of both subspecies fraseri and pascullei colonized the same water system and that the outbreak-causing strain was a new member of the least represented subspecies pascullei. We used partial sequence based typing consensus patterns to mine an international database for additional representatives of fraseri and pascullei subspecies. As a result, we identified 46 sequence types (STs) belonging to subspecies fraseri and two STs belonging to subs

SUBMITTER: Kozak-Muiznieks NA 

PROVIDER: S-EPMC9014860 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature