Platelets fine-tune effector responses of naive CD4⁺ T cells via platelet factor 4-regulated transforming growth factor β signaling.

ABSTRACT:

Background and aim

Platelets are an able regulator of CD4⁺ T cell immunity. Herein, the mechanisms underlying platelet-regulated effector responses of naïve CD4⁺ T (Tn) cells were investigated.

Methods

Platelet-Tn cell co-cultures of human cells, genetically modified murine models, and high-throughput bioinformatic analyses were combined to elucidate molecular mechanisms of platelet-dependent regulation.

Results

Platelets exerted sophisticated regulation on effector responses of type 1, 2, and 17 T helper (Th1/Th2/Th17) and regulatory T (Treg) cells, in time-, concentration-, and organ-dependent manners and with close cooperation of transforming growth factor β (TGFβ) and platelet factor 4 (PF4). PF4 at low concentrations reinforced TGFβ signalin

SUBMITTER: Min Y 

PROVIDER: S-EPMC9016031 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature