Association of vitamin K with cognitive decline and neuropathology in community-dwelling older persons.
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ABSTRACT:
SUBMITTER: Booth SL
PROVIDER: S-EPMC9019903 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Association of vitamin K with cognitive decline and neuropathology in community-dwelling older persons.
Booth Sarah L SL Shea M Kyla MK Barger Kathryn K Leurgans Sue E SE James Bryan D BD Holland Thomas M TM Agarwal Puja P Fu Xueyan X Wang Jifan J Matuszek Gregory G Schneider Julie A JA
Alzheimer's & dementia (New York, N. Y.) 20220420 1
Higher vitamin K intakes have been associated with better cognitive function, suggestive of a vitamin K mechanistic effect or simply reflective of a healthy diet. To test the hypothesis that brain vitamin K is linked to cognitive decline and dementia, vitamin K concentrations were measured in four brain regions, and their associations with cognitive and neuropathological outcomes were estimated in 325 decedents of the Rush Memory and Aging Project. Menaquinone-4 (MK4) was the main vitamin K form ...[more]
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