Involvement of cortico-efferent tracts in flail arm syndrome: a tract-of-interest-based DTI study.

ABSTRACT:

Background

Flail arm syndrome is a restricted phenotype of motor neuron disease that is characterized by progressive, predominantly proximal weakness and atrophy of the upper limbs.

Objective

The study was designed to investigate specific white matter alterations in diffusion tensor imaging (DTI) data from flail arm syndrome patients using a hypothesis-guided tract-of-interest-based approach to identify in vivo microstructural changes according to a neuropathologically defined amyotrophic lateral sclerosis (ALS)-related pathology of the cortico-efferent tracts.

Methods

DTI-based white matter mapping was performed both by an unbiased voxel-wise statistical comparison and by a hypothesis-guided tract-wise analysis of fractional anisotropy (FA) maps according to the neur

SUBMITTER: Rosenbohm A 

PROVIDER: S-EPMC9021061 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature