Calreticulin Shortage Results in Disturbance of Calcium Storage, Mitochondrial Disease, and Kidney Injury.

ABSTRACT: Renal Ca²⁺ reabsorption plays a central role in the fine-tuning of whole-body Ca²⁺ homeostasis. Here, we identified calreticulin (Calr) as a missing link in Ca²⁺ handling in the kidney and showed that a shortage of Calr results in mitochondrial disease and kidney pathogenesis. We demonstrated that Calr^+/- mice displayed a chronic physiological low level of Calr and that this was associated with progressive renal injury manifested in glomerulosclerosis and tubulointerstitial damage. We found that Calr^+/- kidney cells suffer from a disturbance in functionally active calcium stores and decrease in Ca²⁺ storage capacity. Consequently, the kidney cells displayed an abnormal activation of Ca²⁺ signaling and NF-κB pathwa

SUBMITTER: Tayyeb A 

PROVIDER: S-EPMC9025518 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature