Dataset Information

Subcortical and Cerebellar Neural Correlates of Prodromal Alzheimer's Disease with Prolonged Sleep Latency.

ABSTRACT:

Background

Despite the important associations among sleep, Alzheimer's disease (AD), subcortical structures, and the cerebellum, structural and functional magnetic resonance imaging (MRI) with regard to these regions and sleep on patients in AD trajectory are scarce.

Objective

This study aimed to evaluate the influence of prolonged sleep latency on the structural and functional alterations in the subcortical and cerebellar neural correlates in amyloid-β positive amnestic mild cognitive impairment patients (Aβ+aMCI).

Methods

A total of 60 patients with aMCI who were identified as amyloid positive ([18F] flutemetamol+) were recruited in the study, 24 patients with normal sleep latency (aMCI-n) and 36 patients prolonged sleep latency (aMCI-p). Cortical thickness and volumes between the two groups were compared. Volumetric analyses were implemented on the brainstem, thalamus, and hippocampus. Subcortical and cerebellar resting state functional connectivity (FC) differences were measured between the both groups through seed-to-voxel analysis. Additionally, group x Aβ interactive effects on FC values were tested with a general linear model.

Result

There was a significantly decreased brainstem volume in aMCI-p subjects. We observed a significant reduction of the locus coeruleus (LC) FC with frontal, temporal, insular cortices, hippocampus, and left thalamic FC with occipital cortex. Moreover, the LC FC with occipital cortex and left hippocampal FC with frontal cortex were increased in aMCI-p subjects. In addition, there was a statistically significant group by regional standardized uptake value ratio interactions discovered in cerebro-cerebellar networks.

Conclusion

The aforementioned findings suggest that prolonged sleep latency may be a detrimental factor in compromising structural and functional correlates of subcortical structures and the cerebellum, which may accelerate AD pathophysiology.

SUBMITTER: Um YH

PROVIDER: S-EPMC9028620 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Subcortical and Cerebellar Neural Correlates of Prodromal Alzheimer's Disease with Prolonged Sleep Latency.

Um Yoo Hyun YH Wang Sheng-Min SM Kang Dong Woo DW Kim Nak-Young NY Lim Hyun Kook HK

Journal of Alzheimer's disease : JAD 20220101 2

<h4>Background</h4>Despite the important associations among sleep, Alzheimer's disease (AD), subcortical structures, and the cerebellum, structural and functional magnetic resonance imaging (MRI) with regard to these regions and sleep on patients in AD trajectory are scarce.<h4>Objective</h4>This study aimed to evaluate the influence of prolonged sleep latency on the structural and functional alterations in the subcortical and cerebellar neural correlates in amyloid-β positive amnestic mild cogn ...[more]

PMID: 35068468

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Dataset Information

Subcortical and Cerebellar Neural Correlates of Prodromal Alzheimer's Disease with Prolonged Sleep Latency.

Background

Objective

Methods

Result

Conclusion

Publications

Subcortical and Cerebellar Neural Correlates of Prodromal Alzheimer's Disease with Prolonged Sleep Latency.

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