Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus.

ABSTRACT:

Introduction

Insulin resistance is associated with a pro-inflammatory state increasing the risk for complications in patients with type 2 diabetes mellitus (T2DM). In addition to its chronobiotic effects, the pineal hormone melatonin is known to exert anti-inflammatory and antioxidant effects. Melatonin was also suggested to affect insulin secretion. The aim of this study was therefore to investigate the effect of melatonin on inflammation in diabetic rats and to study the possible involvement of the melatonin receptor, MT2.

Materials and methods

Male Sprague Dawley rats were randomly divided into four experimental groups (n = 10 per group): (1) control, (2) streptozotocin/nicotinamide induced diabetes type 2 (T2DM), (3) T2DM treated with melatonin (500 µg/kg/day), an

SUBMITTER: Yapislar H 

PROVIDER: S-EPMC9029934 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature