Copper-catalyzed thioketalization of enones featuring trifluoromethyl groups.

ABSTRACT: Synthetic methods for the preparation of thioketals featuring CF₃ groups are rare. Here, we have developed a copper-catalyzed thioketalization of enones bearing CF₃ groups and various mercaptans. 24 thioketal molecules have been obtained with moderate to excellent yield. Meanwhile, a preparative scale experiment has been performed giving over 95% yield. This work allows the straightforward formation of thioketals containing CF₃ groups and unsaturated double bonds.

SUBMITTER: Zhang T 

PROVIDER: S-EPMC9033665 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature