Epigenetic Regulation of Immune and Inflammatory Responses in Rheumatoid Arthritis.

ABSTRACT:

Purpose

Rheumatoid arthritis (RA) is a disease associated with multiple factors. Epigenetics can affect gene expression without altering the DNA sequence. In this study, we aimed to comprehensively analyze epigenetic regulation in RA.

Methods

Using the Gene Expression Omnibus database, we identified a methylation chip, RNA-sequencing, and miRNA microarray for RA. First, we searched for DNA methylation, genes, and miRNAs associated with RA using differential analysis. Second, we determined the regulatory networks for RA-specific methylation, miRNA, and m6A using cross-analysis. Based on these three regulatory networks, we built a comprehensive epigenetic regulatory network and identified hub genes.

Results

Using a differential analysis, we identified 16,852 differentia

SUBMITTER: Chen Q 

PROVIDER: S-EPMC9035598 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature