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Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes.

ABSTRACT: C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions are demonstrated in good to excellent conversions to furnish C (sp³)-N bonds on DNA. This DNA-compatible transformation has strong potentials for the application into DNA-encoded library synthesis.

SUBMITTER: Cai K

PROVIDER: S-EPMC9035600 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes.

Cai Kunliang K Ran Yuzhao Y Sun Wenbo W Gao Sen S Li Jin J Wan Jinqiao J Liu Guansai G

Frontiers in chemistry 20220411

C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions are demonstrated in good to excellent conversions to furnish C (sp3)-N bonds on DNA. This DNA-compatible transformation has strong potentials for the application into DNA-encoded library synthesis. ...[more]

PMID: 35480389

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