Upper respiratory tract bacterial-immune interactions during respiratory syncytial virus infection in infancy.

ABSTRACT:

Background

The risk factors determining short- and long-term morbidity following acute respiratory infection (ARI) due to respiratory syncytial virus (RSV) in infancy remain poorly understood.

Objectives

Our aim was to examine the associations of the upper respiratory tract (URT) microbiome during RSV ARI in infancy with the acute local immune response and short- and long-term clinical outcomes.

Methods

We characterized the URT microbiome by 16S ribosomal RNA sequencing and assessed the acute local immune response by measuring 53 immune mediators with high-throughput immunoassays in 357 RSV-infected infants. Our short- and long-term clinical outcomes included several markers of disease severity and the number of wheezing episodes in the fourth year of life, respective

SUBMITTER: Rosas-Salazar C 

PROVIDER: S-EPMC9036861 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature