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Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the S_N2 substitution/condensation/tautomerization cascade process.

ABSTRACT: A simple and efficient cascade reaction was developed for the construction of hydroxy substituted indolizines from pyrrole-2-carbaldehydes and commercially available 4-halogenated acetoacetic esters. Their optical properties were also evaluated.

SUBMITTER: Duan G

PROVIDER: S-EPMC9036982 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the SN2 substitution/condensation/tautomerization cascade process.

Duan Guiyun G Liu Hao H Zhang Liqing L Yuan Chunhao C Li Yongchao Y Ge Yanqing Y

RSC advances 20210723 41

A simple and efficient cascade reaction was developed for the construction of hydroxy substituted indolizines from pyrrole-2-carbaldehydes and commercially available 4-halogenated acetoacetic esters. Their optical properties were also evaluated. ...[more]

PMID: 35478892

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