KRP-203 Is a Desirable Immunomodulator for Islet Allotransplantation.

ABSTRACT:

Background

The current standard immunosuppressive regimens, calcineurin inhibitors, have diabetogenic and anti-vascularization effects on islet grafts. KRP-203, a sphingosine-1-phosphate functional antagonist, exerts its immunomodulatory function through lymphocyte sequestration. However, the effect of this antagonist on islets is unclear. We examined the effect of KRP-203 on the islet function and vascularization and sought a calcineurin-free regimen for islet allotransplantation.

Methods

KRP-203 was administered for 14 d to mice, then diabetogenic effect was evaluated by blood glucose levels and a glucose tolerance test. Static glucose stimulation, the breathing index, and insulin/DNA were examined using isolated islets. Islet neovascularization was evaluated using a multi

SUBMITTER: Fathi I 

PROVIDER: S-EPMC9038237 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature