The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results.

ABSTRACT: Cerebral ischemia and reperfusion initiate cellular events in brain that lead to neurological disability. Investigating these cellular events provides ample targets for developing new treatments. Despite considerable work, no such therapy has translated into successful stroke treatment. Among other issues-such as incomplete mechanistic knowledge and faulty clinical trial design-a key contributor to prior translational failures may be insufficient scientific rigor during preclinical assessment: nonblinded outcome assessment; missing randomization; inappropriate sample sizes; and preclinical assessments in young male animals that ignore relevant biological variables, such as age, sex, and relevant comorbid diseases. Promising results are rarely replicated in multiple laboratories. We sought

SUBMITTER: Lyden PD 

PROVIDER: S-EPMC9038686 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature