NS3/4A helicase inhibitory alkaloids from Aptenia cordifolia as HCV target.

ABSTRACT: Chemical investigation of Aptenia cordifolia roots extract, using chromatographic and spectroscopic techniques, resulted in isolation and identification of eight known compounds. The basic ethyl acetate fraction (alkaloidal fraction) afforded O-methylsceletenone, epinine, 4-methoxy phenethylamine, and N-methyl tyramine while, the acidic ethyl acetate fraction (non-alkaloidal fraction) afforded only cis-N-coumaroyl tyramine. Moreover, the petroleum ether fraction afforded capric acid, tricosanol, and a mixture of β-sitosterol & stigma sterol. Upon screening of anti HCV activity of these three fractions, only the basic ethyl acetate fraction had high activity against HCV with an IC₅₀ value equal to 2.4 μg mL^-1 which provoked us to carry out s

SUBMITTER: Elgoud Said AA 

PROVIDER: S-EPMC9042107 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature