Identification of Potential Vaccine Candidates Against SARS-CoV-2 to Fight COVID-19: Reverse Vaccinology Approach.

ABSTRACT:

Background

The recent emergence of COVID-19 has caused an immense global public health crisis. The etiological agent of COVID-19 is the novel coronavirus SARS-CoV-2. More research in the field of developing effective vaccines against this emergent viral disease is indeed a need of the hour.

Objective

The aim of this study was to identify effective vaccine candidates that can offer a new milestone in the battle against COVID-19.

Methods

We used a reverse vaccinology approach to explore the SARS-CoV-2 genome among strains prominent in India. Epitopes were predicted and then molecular docking and simulation were used to verify the molecular interaction of the candidate antigenic peptide with corresponding amino acid residues of the host protein.

Results

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SUBMITTER: Gupta E 

PROVIDER: S-EPMC9048139 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature