Lactobacillus fermentum HFY06 reduced CCl₄-induced hepatic damage in Kunming mice.

ABSTRACT: This study was conducted to investigate the preventative effect of Lactobacillus fermentum HFY06 on carbon tetrachloride (CCl₄)-induced liver injury in Kunming mice. Mice were treated with HFY06, then liver damage was induced using CCl₄. Evaluation indicators included the activities of aspartate aminotransferase (AST), triglycerides (TG), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) in serum; cytokines levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in serum; and related gene expressions of nuclear factor-κB (NF-κB), TNF-α, cyclooxygenase-2 (COX-2), copper/zinc superoxide dismutase (Cu/Zn-SOD), manganese superoxide dismutase (Mn-SOD), and catalase (CAT). Liver tissue was stained

SUBMITTER: Li F 

PROVIDER: S-EPMC9048285 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature