Blood Pressure Variation and Subclinical Brain Disease.

ABSTRACT:

Background

Large blood pressure (BP) variability may contribute to stroke and dementia, but the mechanisms are largely unknown.

Objectives

This study investigated the association of BP variation, considering its magnitude and direction, with the presence and progression of subclinical brain disease in the general population.

Methods

This study included 2,348 participants age ≥55 years from a prospective cohort study. BP was measured at each visit every 3 to 4 years from 1990 onward. Brain magnetic resonance imaging (MRI) was performed at all visits from 2005 onward. The authors primarily assessed variation as the absolute difference in BP divided by the mean over 2 sequential visits for both systolic BP (SBP) and diastolic BP (DBP), and further assessed the direction

SUBMITTER: Ma Y 

PROVIDER: S-EPMC9049233 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature