Palladium-catalysed difluoroolefination of benzyl tosylates toward the synthesis of gem-difluoro-2-trifluromethyl styrene derivatives.

ABSTRACT: We have presented an efficient method to access gem-difluoro-2-trifluromethyl styrene derivatives via palladium catalysis. This method features mild reaction conditions, broad substrate scope and good product yields. Moreover, gram-scale reactions demonstrated the robustness and potential of this method. Control experiments revealed that the -CF₃ group was essential to the success of this transformation. Finally, the practicality of this method was successfully proven by three synthetic applications.

SUBMITTER: Xu J 

PROVIDER: S-EPMC9049850 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature