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Palladium-catalysed difluoroolefination of benzyl tosylates toward the synthesis of gem-difluoro-2-trifluromethyl styrene derivatives.

ABSTRACT: We have presented an efficient method to access gem-difluoro-2-trifluromethyl styrene derivatives via palladium catalysis. This method features mild reaction conditions, broad substrate scope and good product yields. Moreover, gram-scale reactions demonstrated the robustness and potential of this method. Control experiments revealed that the -CF₃ group was essential to the success of this transformation. Finally, the practicality of this method was successfully proven by three synthetic applications.

SUBMITTER: Xu J

PROVIDER: S-EPMC9049850 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Palladium-catalysed difluoroolefination of benzyl tosylates toward the synthesis of gem-difluoro-2-trifluromethyl styrene derivatives.

Xu Jie J Liu Jiangjun J Chen Gang G Xiong Baojian B Zhang Xuemei X Lian Zhong Z

RSC advances 20220428 21

We have presented an efficient method to access gem-difluoro-2-trifluromethyl styrene derivatives via palladium catalysis. This method features mild reaction conditions, broad substrate scope and good product yields. Moreover, gram-scale reactions demonstrated the robustness and potential of this method. Control experiments revealed that the -CF3 group was essential to the success of this transformation. Finally, the practicality of this method was successfully proven by ...[more]

PMID: 35497019

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