Antibacterial activity evaluation and mode of action study of novel thiazole-quinolinium derivatives.

ABSTRACT: New antimicrobial agents are urgently needed to address the emergence of multi-drug resistant organisms, especially those active compounds with new mechanisms of action. Based on the molecular structures of the FtsZ inhibitors reported, a variety of thiazole-quinolinium derivatives with aliphatic amino and/or styrene substituents were synthesized from benzothiazolidine derivatives. In the present study, to further explore the antibacterial potential of thiazole-quinolinium derivatives, several Gram-positive and Gram-negative bacteria were treated with the newly modified compounds and the biological effects were studied in detail in order to understand the bactericidal action of the compounds. Our findings reveal that some of these derivatives possess good potent bactericidal activity as th

SUBMITTER: Li Y 

PROVIDER: S-EPMC9052103 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature