<i>Staphylococcus aureus</i> injection drug use-associated bloodstream infections are propagated by community outbreaks of diverse lineages.

ABSTRACT:

Background

The ongoing injection drug use (IDU) crisis in the United States has been complicated by an emerging epidemic of Staphylococcus aureus IDU-associated bloodstream infections (IDU-BSI).

Methods

We performed a case-control study comparing S. aureus IDU-BSI and non-IDU BSI cases identified in a large US Midwestern academic medical center between Jan 1, 2016 and Dec 21, 2019. We obtained the whole-genome sequences of 154 S. aureus IDU-BSI and 91 S. aureus non-IDU BSI cases, which were matched with clinical data. We performed phylogenetic and comparative genomic analyses to investigate clonal expansion of lineages and molecular features characteristic of IDU-BSI isolates.

Results

Here we show that patients with IDU-BSI experience longe

SUBMITTER: Marks LR 

PROVIDER: S-EPMC9053277 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature