A highly green approach towards aromatic nitro group substitutions: catalyst free reactions of nitroimidazoles with carbon nucleophiles in water.

ABSTRACT: We have successfully developed a flexible green aqueous approach for the formation of a carbon-carbon bond by the reaction of highly-enolizable carbanions (mostly derived from 1,3-dicarbonyl compounds) with an aromatic carbon bearing a nitro group. The key step involves a nucleophilic displacement reaction. All newly synthesized compounds were unambiguously characterized via various spectroscopic techniques including NMR, mass spectrometry and single-crystal X-ray diffraction as applicable. We believe that our study will be useful in providing new insights into catalyst-free water-mediated nucleophilic substitution reactions.

SUBMITTER: Shah SR 

PROVIDER: S-EPMC9054563 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature