Revision of the structure of isochaetoglobosin D_b based on NMR analysis and biosynthetic consideration.

ABSTRACT: Isochaetoglobosin D_b is a new chaetoglobosin possessing a unique 3,4-substituted pyrrole ring isolated and named by Qiu et al., and it is different from any one of the 14 sub-types in the macrocyclic ring of chaetoglobosins classified in our previous work. Its chemical shift values, coupling constants and biosynthetic consideration implied that the proposed structure of isochaetoglobosin D_b was incorrect. In this report, based on detailed NMR data analysis together with biosynthetic consideration, the structure of isochaetoglobosin D_b is suggested to be revised to that of penochalasin C. The NMR spectra of penochalasin C measured in the same solvent (DMSO-d ₆) as that of isochaetoglobosin D_b supported the above conclusion

SUBMITTER: Wang YD 

PROVIDER: S-EPMC9055075 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature