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Praseodymium promotes B-Z transition in self-assembled DNA nanostructures.


ABSTRACT: Millimolar concentrations of PrCl3 can induce sequence-specific B-Z transition in various-self-assembled branched DNA (bDNA) nanostructures. Competitive dye binding and thermal kinetics suggest that the phosphate backbone and grooves of bDNA are wrapped with Pr3+ for stabilizing the Z-bDNA. Application of EDTA can convert Z-DNA back to the B-form.

SUBMITTER: Bhanjadeo MM 

PROVIDER: S-EPMC9060621 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Praseodymium promotes B-Z transition in self-assembled DNA nanostructures.

Bhanjadeo Madhabi M MM   Subudhi Umakanta U  

RSC advances 20190101 8


Millimolar concentrations of PrCl<sub>3</sub> can induce sequence-specific B-Z transition in various-self-assembled branched DNA (bDNA) nanostructures. Competitive dye binding and thermal kinetics suggest that the phosphate backbone and grooves of bDNA are wrapped with Pr<sup>3+</sup> for stabilizing the Z-bDNA. Application of EDTA can convert Z-DNA back to the B-form. ...[more]

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