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Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C-H bonds utilizing amino acids as a directing group.

ABSTRACT: The nickel(ii)-catalyzed ortho-arylation of unactivated C-H bonds utilizing amino acids as directing groups with aryl iodides or bromides as coupling electrophiles is described. This protocol features excellent mono-selectivity, good regioselectivity, and wide functional group tolerance. Additionally, the obtained products bearing a biaryl motif and an amino acid represent bioactive molecules with wide bioactivities.

SUBMITTER: Cong Z

PROVIDER: S-EPMC9062466 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C-H bonds utilizing amino acids as a directing group.

Cong Zhanqing Z Gao Feng F Liu Hong H

RSC advances 20190408 19

The nickel(ii)-catalyzed ortho-arylation of unactivated C-H bonds utilizing amino acids as directing groups with aryl iodides or bromides as coupling electrophiles is described. This protocol features excellent mono-selectivity, good regioselectivity, and wide functional group tolerance. Additionally, the obtained products bearing a biaryl motif and an amino acid represent bioactive molecules with wide bioactivities. ...[more]

PMID: 35515296

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