Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C-H bonds utilizing amino acids as a directing group.

ABSTRACT: The nickel(ii)-catalyzed ortho-arylation of unactivated C-H bonds utilizing amino acids as directing groups with aryl iodides or bromides as coupling electrophiles is described. This protocol features excellent mono-selectivity, good regioselectivity, and wide functional group tolerance. Additionally, the obtained products bearing a biaryl motif and an amino acid represent bioactive molecules with wide bioactivities.

SUBMITTER: Cong Z 

PROVIDER: S-EPMC9062466 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature