Characterization of rapid weight gain phenotype in children with narcolepsy.

ABSTRACT:

Objectives

To characterize the rapid weight gain (RWG) phenotype associated with the onset of childhood narcolepsy and to determine whether it could constitute a marker of severity of the disease.

Methods

RWG was defined using the BMI z-score slope reported to one year (>0.67 SD) from symptom onset to disease diagnosis. We compared the clinical, metabolic, and sleep characteristics between patients with or without RWG at diagnosis. Pharmacological management, anthropometric, and clinical progression were also evaluated during the follow-up.

Results

A total of 84 de novo narcoleptic pediatric patients were included; their median age at diagnosis was 12.0 years; 59.5% boys, 90.5% cataplexy, and 98.7% HLA-DQB1*06:02, 57% had RWG profile. RWG patients were younger at diag

SUBMITTER: Zhang M 

PROVIDER: S-EPMC9062543 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature