Long-Term and Clinically Relevant Full-Thickness Human Skin Equivalent for Psoriasis.

ABSTRACT: Psoriasis is an incurable, immune-mediated inflammatory disease characterized by the hyperproliferation and abnormal differentiation of keratinocytes. To study in depth the pathogenesis of this disease and possible therapy options suitable, pre-clinical models are required. Three-dimensional skin equivalents are a potential alternative to simplistic monolayer cultures and immunologically different animal models. However, current skin equivalents lack long-term stability, which jeopardizes the possibility to simulate the complex disease-specific phenotype followed by long-term therapeutic treatment. To overcome this limitation, the cell coating technique was used to fabricate full-thickness human skin equivalents (HSEs). This rapid and scaffold-free fabrication method relies on coating cell

SUBMITTER: Singh S 

PROVIDER: S-EPMC9062876 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature