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Synthesis and anticancer activity novel dimeric azatriperoxides.

ABSTRACT: An efficient method was developed for the synthesis of tetra(spirocycloalkane)-substituted α,ω-di(1,2,4,5,7,8-hexaoxa-10-azacycloundecan-10-yl)alkanes by a ring transformation reaction of 3,6-di(spirocycloalkane)-substituted 1,2,4,5,7,8,10-heptaoxacycloundecanes with α,ω-alkanediamines (1,4-butane-, 1,5-pentane-, 1,7-heptane-, 1,8-octane- and 1,10-decanediamines) catalyzed by Sm(NO₃)₃/γ-Al₂O₃. Using flow cytometry, it was shown for the first time that synthesized dimeric azatriperoxides are efficient apoptosis inducers with Jurkat, K562, U937, and Hek296.

SUBMITTER: Makhmudiyarova NN

PROVIDER: S-EPMC9064891 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Synthesis and anticancer activity novel dimeric azatriperoxides.

Makhmudiyarova Nataliya N NN Ishmukhametova Irina R IR Dzhemileva Lilya U LU Tyumkina Tatyana V TV D'yakonov Vladimir A VA Ibragimov Askhat G AG Dzhemilev Usein M UM

RSC advances 20190617 33

An efficient method was developed for the synthesis of tetra(spirocycloalkane)-substituted α,ω-di(1,2,4,5,7,8-hexaoxa-10-azacycloundecan-10-yl)alkanes by a ring transformation reaction of 3,6-di(spirocycloalkane)-substituted 1,2,4,5,7,8,10-heptaoxacycloundecanes with α,ω-alkanediamines (1,4-butane-, 1,5-pentane-, 1,7-heptane-, 1,8-octane- and 1,10-decanediamines) catalyzed by Sm(NO3)3/γ-Al2O3. Using flow cytometry, it was shown for the first time that ...[more]

PMID: 35516904

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