Anaplastic thyroid cancer: genome-based search for new targeted therapy options.

ABSTRACT:

Objective

Anaplastic thyroid cancer (ATC) is one of the most lethal human cancers with meager treatment options. We aimed to identify the targeted drugs already approved by the Food and Drug Administration (FDA) for solid cancer in general, which could be effective in ATC.

Design

Database mining.

Methods

FDA-approved drugs for targeted therapy were identified by screening the databases of MyCancerGenome and the National Cancer Institute. Drugs were linked to the target genes by querying Drugbank. Subsequently, MyCancerGenome, CIViC, TARGET and OncoKB were mined for genetic alterations which are predicted to lead to drug sensitivity or resistance. We searched the Cancer Genome Atlas database (TCGA) for patients with ATC and probed their sequencing data for genetic alte

SUBMITTER: Hescheler DA 

PROVIDER: S-EPMC9066601 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature