Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells.

ABSTRACT: The extracellular matrix component biglycan (BGN) plays an essential role in various physiological and pathophysiological processes. A deficient BGN expression associated with reduced immunogenicity was found in HER-2/neu-overexpressing cells. To determine whether BGN is suppressed by oncogene-driven regulatory networks, the expression and function of BGN was analyzed in murine and human BGN^low/BGN^high K-RAS^G12V-transformed model systems as well as in different patients' datasets of colorectal carcinoma (CRC) lesions. K-RAS-mutated CRC tissues expressed low BGN mRNA and protein levels when compared to normal colon epithelial cells, which was associated with a reduced patients' survival. Transfection of BGN in murine and human BGN^low K-RAS-express

SUBMITTER: Subbarayan K 

PROVIDER: S-EPMC9067524 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature